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  3. Genital functions
Medical and paramedical


Genital functions

Genital function in patients with trisomy 21 is characterized by primary hypogonadism, cryptorchidism, micropenis, a 3-4 times higher risk of testicular germ cell tumors in men, and early menopause in women. Apart from an earlier and smaller growth peak, puberty is not very different from in the general population. Lastly, the fertility of patients with trisomy 21 is a very topical ethical issue that merits our full attention.


In this video and accompanying technical sheet, Dr. Hervé Walti, a pediatrician at the Jérôme Lejeune Institute, tells you more about all these matters.

See below for the presentation accompanying this video on “genital function”.

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  • Xing JS, Bai ZM. Is testicular dysgenesis syndrome a genetic, endocrine, or environmental disease, or an unexplained reproductive disorder? Life Sci. 2018 Feb 1;194:120-129. doi: 10.1016/j.lfs.2017.11.039. Epub 2017 Nov 26. PMID: 29183799.
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