Diabetes mellitus

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Diabetes mellitus

Home page
Contents
Diabetes mellitus

22 Jul 2022

Medical and paramedical

ENDOCRINE MANIFESTATIONS

CHAPTER OUTLINE

1- Thyroid dysfunctions

2- Diabetes mellitus

3- Genital functions

4- Statural growth

5- Bone health

6- Overweight and obesity

Type I diabetes is 3-10 times more frequent in patients with trisomy 21 than in the general population. It also has earlier onset, and is diagnosed 1 in 5 times by the age of 2 years. Most frequently, it is an autoimmune pathology like the thyroid pathologies with which it is often associated. Type II diabetes is also slightly more frequent than in the general population, with the same risk factors. Lifelong vigilance is therefore required to ensure early diagnosis and treatment of diabetes mellitus for patients with trisomy 21 and to avoid its complications.

In this video and accompanying technical sheet, Dr. Hervé Walti, a pediatrician at the Jérôme Lejeune Institute, tells you more.

See below for the presentation accompanying this video on “diabetes mellitus”.

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Johnson MB, De Franco E, Greeley SAW, Letourneau LR, Gillespie KM; International DS-PNDM Consortium, Wakeling MN, Ellard S, Flanagan SE, Patel KA, Hattersley AT. Trisomy 21 Is a Cause of Permanent Neonatal Diabetes That Is Autoimmune but Not HLA Associated. Diabetes. 2019 Jul;68(7):1528-1535. doi: 10.2337/db19-0045. Epub 2019 Apr 8. PMID: 30962220; PMCID: PMC6609990.

Moreau M, Benhaddou S, Dard R, Tolu S, Hamzé R, Vialard F, Movassat J, Janel N. Metabolic Diseases and Down Syndrome: How Are They Linked Together? Biomedicines. 2021 Feb 22;9(2):221. doi: 10.3390/biomedicines9020221. PMID: 33671490; PMCID: PMC7926648.
Mortimer GL, Gillespie KM. Early Onset of Autoimmune Diabetes in Children with Down Syndrome-Two Separate Aetiologies or an Immune System Pre-Programmed for Autoimmunity? Curr Diab Rep. 2020 Aug 25;20(9):47. doi: 10.1007/s11892-020-01318-8. PMID: 32839884; PMCID: PMC7445156.
Stolz U, Saur F, Gugler E. Das hyperosmolare, nicht-ketogene Coma diabeticum beim Kind [Hyperosmolar nonketotic diabetic coma in children]. Helv Paediatr Acta. 1977 Jul;32(2):155-63. German. PMID: 154487