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  3. Vision disorders in individuals with trisomy 21
Medical and paramedical

OPHTHALMOLOGICAL PATHOLOGIES

 

Vision disorders

troubles_vision_trisomie_21

The frequency of visual impairment in adults and children with Down’s syndrome is explained by the high prevalence of refractive disorders (hypermetropia, myopia, astigmatism, etc.), the presence of accommodation disorders (present in 2 to 3 cases out of 4 in the Down’s syndrome population) and the existence of a significant drop in visual acuity from childhood onwards.

 

Dr. Hervé Walti, pediatrician at the Institut Jérôme Lejeune, talks to us about this in the video and the accompanying data sheet, making up the third part of our chapter dedicated to ophthalmological pathologies in people with trisomy 21. To read the entire chapter, click on the links on the right of the page.

Discover below the presentation associated with this video on the subject of “Ophthalmological pathologies”.

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  • Al-Bagdady M, Murphy PJ, Woodhouse JM. Development and distribution of refractive error in children with Down’s syndrome. Br J Ophthalmol. 2011. Aug;95(8):1091-7.
  • Anderson HA, Manny RE, Glasser A, Stuebing KK. Static and dynamic measurements of accommodation in individuals with down syndrome. Invest Ophthalmol Vis Sci. 2011 Jan 5;52(1):310-7.
  • Bromham NR, Woodhouse JM, Cregg M, Webb E, Fraser WI. Heart defects and ocular anomalies in children with Down’s syndrome. Br J Ophthalmol. 2002 Dec;86(12):1367-8. .
  • Courage ML, Adams RJ, Reyno S, Kwa PG. Visual acuity in infants and children with Down syndrome. Dev Med Child Neurol. 1994 Jul;36(7):586-93.
  • Courage ML, Adams RJ, Hall EJ. Contrast sensitivity in infants and children with Down syndrome. Vision Res. 1997 Jun;37(11):1545-55.
  • Cregg M, Woodhouse JM, Pakeman VH, Saunders KJ, Gunter HL, Parker M, Fraser WI, Sastry P. Accommodation and refractive error in children with Down syndrome: cross-sectional and longitudinal studies. Invest Ophthalmol Vis Sci. 2001 Jan;42(1):55-63.
  • Cregg M, Woodhouse JM, Stewart RE, Pakeman VH, Bromham NR, Gunter HL, Trojanowska L, Parker M, Fraser WI. Development of refractive error and strabismus in children with Down syndrome. Invest Ophthalmol Vis Sci. 2003 Mar;44(3):1023-30.
  • da Cunha RP, Moreira JB. Ocular findings in Down’s syndrome. Am J Ophthalmol. 1996 Aug;122(2):236-44.
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  • Hashemi H, Mehravaran S, Asgari S, Dehghanian Nasrabadi F. Refractive and Vision Status in Down Syndrome: A Comparative Study. Turk J Ophthalmol. 2021 Aug 27;51(4):199-205.
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  • John FM, Bromham NR, Woodhouse JM, Candy TR. Spatial vision deficits in infants and children with Down syndrome. Invest Ophthalmol Vis Sci. 2004 May;45(5):1566-72.
  • Karlica D, Skelin S, Culic V, Galetović D, Znaor L, Karlica H, Pavelić J. The ophthalmic anomalies in children with Down syndrome in Split-Dalmatian County. Coll Antropol. 2011 Dec;35(4):1115-8.
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  • Krinsky-McHale SJ, Silverman W, Gordon J, Devenny DA, Oley N, Abramov I. Vision deficits in adults with Down syndrome. J Appl Res Intellect Disabil. 2014 May;27(3):247-63.
  • Krinsky-McHale SJ, Jenkins EC, Zigman WB, Silverman W. Ophthalmic disorders in adults with down syndrome. Curr Gerontol Geriatr Res. 2012;2012:974253.
  • Little JA, Woodhouse JM, Lauritzen JS, Saunders KJ. The impact of optical factors on resolution acuity in children with Down syndrome. Invest Ophthalmol Vis Sci. 2007 Sep;48(9):3995-4001.
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  • Ljubic A, Trajkovski V, Stankovic B. Strabismus, refractive errors and nystagmus in children and young adults with Down syndrome. Ophthalmic Genet. 2011 Nov;32(4):204-11.
  • Ljubic A, Trajkovski V. Refractive errors in children and young adults with Down’s syndrome. Acta Ophthalmol. 2011 Jun;89(4):324-7.
  • Muñoz-Ortiz J, Charry-Sánchez JD, Bechara-Arango I, Blanco-Becerra M, Talero-Gutiérrez C, Gomez-Suarez M, de-la-Torre A. Down syndrome: a systematic review Prevalence of ophthalmological manifestations in pediatric and adolescent populations with of the literature. Syst Rev. 2022 Apr 22;11(1):75.
  • Nemes-Dragan IA, et al. Is There an Association between Ocular Pathology and Congenital Heart Defects in Patients with Down Syndrome? Ann Med Health Sci Res. 2021;11:412-415.
  • Nandakumar K, Leat SJ. Bifocals in Down Syndrome Study (BiDS): design and baseline visual function. Optom Vis Sci. 2009 Mar;86(3):196-207.
  • Nucci P, de Pellegrin M, Brancato R. Atlantoaxial dislocation related to instilling eyedrops in a patient with Down’s syndrome. Am J Ophthalmol. 1996 Dec;122(6):908-10.
  • Paudel N, Leat SJ, Adhikari P, Woodhouse JM, Shrestha JB. Visual defects in Nepalese children with Down syndrome. Clin Exp Optom. 2010 Mar;93(2):83-90.
  • PNDS : Protocole National de Diagnostic et de Soins trisomie 21 , HAS 2020
  • Postolache L. Abnormalities of the Optic Nerve in Down Syndrome and Associations With Visual Acuity. Front Neurol. 2019 Jun 14;10:633.
  • Satgunam P, Datta S, Sumalini R. Near vision in individuals with Down syndrome: a vision screening study. Eye (Lond). 2019 Aug;33(8):1254-1260.
  • Terai T, Eda S, Sugasawa J, Tonari M, Matsuo J, Oku H, Ikeda T. Ocular findings in Japanese children with Down syndrome: the course of visual acuity and refraction, and systemic and ocular anomalies. Clin Ophthalmol. 2018 Aug 31;12:1637-1643.
  • Ugurlu A, Altinkurt E. Ophthalmologic Manifestations and Retinal Findings in Children with Down Syndrome. J Ophthalmol. 2020 Feb 7;2020:9726261.
  • Watt T, Robertson K, Jacobs RJ. Refractive error, binocular vision and accommodation of children with Down syndrome. Clin Exp Optom. 2015 Jan;98(1):3-11.
  • de Weger C, Boonstra N, Goossens J. Effects of bifocals on visual acuity in children with Down syndrome: a randomized controlled trial. Acta Ophthalmol. 2019 Jun;97(4):378-393.
  • de Weger C, Boonstra FN, Goossens J. Differences between children with Down syndrome and typically developing children in adaptive behaviour, executive functions and visual acuity. Sci Rep. 2021 Apr 7;11(1):7602.
  • Wilton GJ, Woodhouse R, Vinuela-Navarro V, England R, Woodhouse JM. Behavioural Features of Cerebral Visual Impairment Are Common in Children With Down Syndrome. Front Hum Neurosci. 2021 Jun 14;15:673342.
  • Woodhouse JM, Meades JS, Leat SJ, Saunders KJ. Reduced accommodation in children with Down syndrome. Invest Ophthalmol Vis Sci. 1993 Jun;34(7):2382-7.
  • Woodhouse JM, Pakeman VH, Saunders KJ, Parker M, Fraser WI, Lobo S, Sastry P. Visual acuity and accommodation in infants and young children with Down’s syndrome. J Intellect Disabil Res. 1996 Feb;40 ( Pt 1):49-55.
  • Woodhouse JM, Pakeman VH, Cregg M, Saunders KJ, Parker M, Fraser WI, Sastry P, Lobo S. Refractive errors in young children with Down syndrome. Optom Vis Sci. 1997 Oct;74(10):844-51.
  • Zahidi AA, Vinuela-Navarro V, Woodhouse JM. Different visual development: norms for visual acuity in children with Down’s syndrome. Clin Exp Optom. 2018 Jul;101(4):535-540.
  • Zahidi AAA, McIlreavy L, Erichsen JT, Woodhouse JM. Visual and Refractive Status of Children With Down’s Syndrome and Nystagmus. Invest Ophthalmol Vis Sci. 2022 Feb 1;63(2):28.
  • Zago, Campestrini Harger, Possamai, Schmitt Lobe, Zwicker, Rosendo Fogaça, Marcondes Penha. Association between ocular abnormalities and systemic diseases in Down Syndrome patients. Rev Bras Oftalmol. 2020; 79 (3): 174-9

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