{"id":6051,"date":"2023-12-21T12:18:57","date_gmt":"2023-12-21T11:18:57","guid":{"rendered":"https:\/\/t21learning.institutlejeune.org\/?p=6051"},"modified":"2024-01-05T17:55:48","modified_gmt":"2024-01-05T16:55:48","slug":"regression-catatonia-t21","status":"publish","type":"post","link":"https:\/\/t21learning.institutlejeune.org\/en\/regression-catatonia-t21\/","title":{"rendered":"Regression and Catatonia"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"6051\" class=\"elementor elementor-6051\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bcd2501 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bcd2501\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3d33776\" data-id=\"3d33776\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-739d8ae elementor-widget elementor-widget-text-editor\" data-id=\"739d8ae\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>PSYCHIATRIC MANIFESTATIONS<\/strong><\/p><p><strong>\u00a0<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f3e818e elementor-widget elementor-widget-heading\" data-id=\"f3e818e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Regression and Catatonia<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-94c524a elementor-widget elementor-widget-spacer\" data-id=\"94c524a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4166f5b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4166f5b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-a2f6aac\" data-id=\"a2f6aac\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-68055fa elementor-widget elementor-widget-image\" data-id=\"68055fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"932\" height=\"572\" src=\"https:\/\/t21learning.institutlejeune.org\/wp-content\/uploads\/2023\/12\/regression.jpeg\" class=\"attachment-large size-large wp-image-5948\" alt=\"\" srcset=\"https:\/\/t21learning.institutlejeune.org\/wp-content\/uploads\/2023\/12\/regression.jpeg 932w, https:\/\/t21learning.institutlejeune.org\/wp-content\/uploads\/2023\/12\/regression-300x184.jpeg 300w, https:\/\/t21learning.institutlejeune.org\/wp-content\/uploads\/2023\/12\/regression-768x471.jpeg 768w\" sizes=\"(max-width: 932px) 100vw, 932px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-a45ba83\" data-id=\"a45ba83\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-932f368 elementor-widget elementor-widget-toggle\" data-id=\"932f368\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1541\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1541\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">CHAPTER OUTLINE<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1541\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1541\"><p><a href=\"https:\/\/t21learning.institutlejeune.org\/en\/behavorial-functioning-t21\/\" target=\"_blank\" rel=\"noopener\">1- Behavorial Functioning<\/a><\/p><p>\u00a0<\/p><p><a href=\"https:\/\/t21learning.institutlejeune.org\/en\/autistic-spectrum-disorder-t21\/\" target=\"_blank\" rel=\"noopener\">2- Autistic Spectrum\u00a0<\/a><a href=\"https:\/\/t21learning.institutlejeune.org\/en\/autistic-spectrum-disorder-t21\/\" target=\"_blank\" rel=\"noopener\"> Disorder<\/a><\/p><p>\u00a0<\/p><p><a href=\"https:\/\/t21learning.institutlejeune.org\/en\/adhd-t21\/\" target=\"_blank\" rel=\"noopener\">3- ADHD<\/a><\/p><p>\u00a0<\/p><p><a href=\"https:\/\/t21learning.institutlejeune.org\/en\/depression-t21\/\" target=\"_blank\" rel=\"noopener\">4- Depression<\/a><\/p><p>\u00a0<\/p><p><a href=\"https:\/\/t21learning.institutlejeune.org\/en\/regression-catatonia-t21\/\" target=\"_blank\" rel=\"noopener\"><strong>5- Regression and Catatonia<\/strong><\/a><\/p><p>\u00a0<\/p><p><a href=\"https:\/\/t21learning.institutlejeune.org\/en\/schizophrenia-psychotic-disorders-t21\/\" target=\"_blank\" rel=\"noopener\">6- Schizophrenia and Psychotic Disorders<\/a><\/p><p>\u00a0<\/p><p><a href=\"https:\/\/t21learning.institutlejeune.org\/en\/ocd-related-disorders-t21\/\" target=\"_blank\" rel=\"noopener\">7- OCD and Related Disorders<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-da3cd7c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"da3cd7c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-18c48beb\" data-id=\"18c48beb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6b33d20 elementor-widget elementor-widget-spacer\" data-id=\"6b33d20\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3acff4c elementor-widget elementor-widget-text-editor\" data-id=\"3acff4c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>With psychiatrist Dr. Laura Cretu, Dr. Herv\u00e9 Walti, pediatrician at the Institut J\u00e9r\u00f4me Lejeune, talks about the symptoms of regression and catatonia in people with Down&#8217;s syndrome in this video and accompanying fact sheet.<\/p><p>Discover the entire &#8220;Psychiatric Manifestations&#8221; chapter by clicking on &#8220;Chapter outline&#8221; to the right of the image at the top of the page.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-985d68f elementor-widget elementor-widget-spacer\" data-id=\"985d68f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ed6e280 elementor-widget elementor-widget-video\" data-id=\"ed6e280\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/youtu.be\\\/sLDknvmCT_A&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d879305 elementor-widget elementor-widget-spacer\" data-id=\"d879305\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0594797 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"0594797\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/t21learning.institutlejeune.org\/wp-content\/uploads\/2023\/12\/4.5-Regression-and-Catatonia-EN.pdf\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Download the summary sheet<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2d289a1 elementor-widget elementor-widget-spacer\" data-id=\"2d289a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-09d9e5d elementor-widget elementor-widget-text-editor\" data-id=\"09d9e5d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Discover below the presentation associated with this video.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-057dae3 elementor-widget elementor-widget-spacer\" data-id=\"057dae3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-67fc6d2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"67fc6d2\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-adc6cf2\" data-id=\"adc6cf2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f2192a7 elementor-widget elementor-widget-shortcode\" data-id=\"f2192a7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\"><div class=\"_df_book df-lite\" id=\"df_6053\"  _slug=\"4-5-regression-and-catatonia\" data-title=\"4-5-regression-and-catatonia\" wpoptions=\"true\" thumbtype=\"\" ><\/div><script class=\"df-shortcode-script\" nowprocket type=\"application\/javascript\">window.option_df_6053 = {\"outline\":[],\"autoEnableOutline\":\"false\",\"autoEnableThumbnail\":\"false\",\"overwritePDFOutline\":\"false\",\"direction\":\"1\",\"pageSize\":\"0\",\"source\":\"https:\\\/\\\/t21learning.institutlejeune.org\\\/wp-content\\\/uploads\\\/2023\\\/12\\\/4.5-PDF-Regression-and-Catatonia-EN.pdf\",\"wpOptions\":\"true\"}; if(window.DFLIP && window.DFLIP.parseBooks){window.DFLIP.parseBooks();}<\/script><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4e0f511 elementor-widget elementor-widget-spacer\" data-id=\"4e0f511\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f625a75 elementor-align-justify btn-refs elementor-widget elementor-widget-button\" data-id=\"f625a75\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">See references<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-b720bb6 div-refs div-refs-closed elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b720bb6\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-33c594e\" data-id=\"33c594e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-87397c0 elementor-widget elementor-widget-text-editor\" data-id=\"87397c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>American Psychiatric Association. Obsessive compulsive and related disorders. In Diagnostic and statistical manual of mental disorders (5th ed., 2013).<\/li><li>Benarous X, Consoli A, Raffin M, Bodeau N, Giannitelli M, Cohen D, Olliac B. Validation of the Pediatric Catatonia Rating Scale (PCRS). Schizophr Res. 2016 Oct;176(2-3):378-386.<\/li><li>Cardinale KM, Bocharnikov A, Hart SJ, Baker JA, Eckstein C, Jasien JM, Gallentine W, Worley G, Kishnani PS, Van Mater H. Immunotherapy in selected patients with Down syndrome disintegrative disorder. Dev Med Child Neurol. 2019 Jul;61(7):847-851.<\/li><li>Cohen D, Raffin M, Benarous X, Ferrafiat V., Consoli A. Syndrome catatonique de l\u2019enfant et de l\u2019adolescent : une pathologie rare fr\u00e9quemment associ\u00e9e \u00e0 une cause organique. Bull. Acad. Natle M\u00e9d., 2018, 202, nos 5-6, 1159-1178.<\/li><li>Ghaziuddin M. Catatonia: A Common Cause of Late Regression in Autism. Front Psychiatry. 2021 Oct 28;12:674009.<\/li><li>Hauptman AJ, Cohen D, Dhossche D, Raffin M, Wachtel L, Ferrafiat V. Catatonia in neurodevelopmental disorders: assessing catatonic deterioration from baseline. Lancet Psychiatry. 2023 Mar;10(3):228-234.<\/li><li>Huggard D, Doherty DG, Molloy EJ. Immune Dysregulation in Children With Down Syndrome. Front Pediatr. 2020 Feb 27;8:73.<\/li><li>Jacobs J, Schwartz A, McDougle CJ, Skotko BG. Rapid clinical deterioration in an individual with Down syndrome. Am J Med Genet A. 2016 Jul;170(7):1899-902.<\/li><li>Jakubowicz B, Baptista A, Ravel A, Cieuta C, Mircher C, Cohen D, Consoli A, Raffin M. Catatonia in Down&#8217;s syndrome: An under-recognized syndrome during regression. Schizophr Res. 2023 Sep 14;261:107-109.<\/li><li>Malle L, Patel RS, Martin-Fernandez M, Stewart OJ, Philippot Q, Buta S, Richardson A, Barcessat V, Taft J, Bastard P, Samuels J, Mircher C, Rebillat AS, Maillebouis L, Vilaire-Meunier M, Tuballes K, Rosenberg BR, Trachtman R, Casanova JL, Notarangelo LD, Gnjatic S, Bush D, Bogunovic D. Autoimmunity in Down&#8217;s syndrome via cytokines, CD4 T cells and CD11c+ B cells. Nature. 2023 Mar;615(7951):305-314.<\/li><li>Mircher C, Cieuta-Walti C, Marey I, Rebillat AS, Cretu L, Milenko E, Conte M, Sturtz F, Rethore MO, Ravel A. Acute Regression in Young People with Down Syndrome. Brain Sci. 2017 May 27;7(6):57.<\/li><li>Protocole National de Diagnostic et de Soins (PNDS). Syndrome catatonique (2021): <a href=\"https:\/\/www.has-sante.fr\/upload\/docs\/application\/pdf\/2021-10\/2021_defiscience_pnds_syndrome_catatonique_texte_pnds.pdf\">https:\/\/www.has-sante.fr\/upload\/docs\/application\/pdf\/2021-10\/2021_defiscience_pnds_syndrome_catatonique_texte_pnds.pdf<\/a><\/li><li>Poumeaud F, Mircher C, Smith PJ, Faye PA, Sturtz FG. Deciphering the links between psychological stress, depression, and neurocognitive decline in patients with Down syndrome. 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Pediatrics. 2020 Jun;145(6):e20192939.<\/li><li>Santoro SL, Cannon S, Capone G, Franklin C, Hart SJ, Hobensack V, Kishnani PS, Macklin EA, Manickam K, McCormick A, Nash P, Oreskovic NM, Patsiogiannis V, Steingass K, Torres A, Valentini D, Vellody K, Skotko BG. Unexplained regression in Down syndrome: 35 cases from an international Down syndrome database. Genet Med. 2020 Apr;22(4):767-776.<\/li><li>Santoro JD, Partridge R, Tanna R, Pagarkar D, Khoshnood M, Rehmani M, Kammeyer RM, Gombolay GY, Fisher K, Conravey A, El-Dahr J, Christy AL, Patel L, Manning MA, Van Mater H, Rafii MS, Quinn EA. Evidence of neuroinflammation and immunotherapy responsiveness in individuals with down syndrome regression disorder. 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Am J Med Genet A. 2022c Oct;188(10):3049-3062.<\/li><li>Spinazzi NA, Santoro JD, Pawlowski K, Anzueto G, Howe YJ, Patel LR, Baumer NT. Co-occurring conditions in children with Down syndrome and autism: a retrospective study. J Neurodev Disord. 2023 Mar 2;15(1):9.<\/li><li>Stein DS, Munir KM, Karweck AJ, Davidson EJ, Stein MT. Developmental Regression, Depression, and Psychosocial Stress in an Adolescent with Down Syndrome. J Dev Behav Pediatr. 2017 Feb\/Mar;38 Suppl 1(Suppl 1):S26-S28.<\/li><li>Worley G, Crissman BG, Cadogan E, Milleson C, Adkins DW, Kishnani PS. Down Syndrome Disintegrative Disorder: New-Onset Autistic Regression, Dementia, and Insomnia in Older Children and Adolescents With Down Syndrome. J Child Neurol. 2015 Aug;30(9):1147-52.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad117e9 elementor-widget elementor-widget-html\" data-id=\"ad117e9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<script>\n    jQuery(\".btn-refs\").on(\"click\", function(e){\n        e.preventDefault()\n        jQuery(\".div-refs\").toggleClass(\"div-refs-closed\")\n    })\n<\/script>\n\n<style>\nbody:not(.elementor-editor-active) .div-refs{\n    transition: 0.3s;\n    max-height: 1000px;\n}\n    body:not(.elementor-editor-active) .div-refs-closed{\n        max-height: 0;\n        overflow: hidden !important;\n    }\n<\/style>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section 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