{"id":4233,"date":"2023-06-14T10:21:08","date_gmt":"2023-06-14T08:21:08","guid":{"rendered":"https:\/\/t21learning.institutlejeune.org\/?p=4233"},"modified":"2023-11-22T17:04:31","modified_gmt":"2023-11-22T16:04:31","slug":"posterior-segment-eye-diseases-in-individuals-with-trisomy-21","status":"publish","type":"post","link":"https:\/\/t21learning.institutlejeune.org\/en\/posterior-segment-eye-diseases-in-individuals-with-trisomy-21\/","title":{"rendered":"Posterior segment eye diseases in individuals with trisomy 21"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"4233\" class=\"elementor elementor-4233\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bcd2501 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bcd2501\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3d33776\" data-id=\"3d33776\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-739d8ae elementor-widget elementor-widget-text-editor\" data-id=\"739d8ae\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>OPHTHALMOLOGICAL PATHOLOGIES<\/strong><\/p><p><strong>\u00a0<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f3e818e elementor-widget elementor-widget-heading\" data-id=\"f3e818e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Posterior segment eye diseases<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-94c524a elementor-widget elementor-widget-spacer\" data-id=\"94c524a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4166f5b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4166f5b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-a2f6aac\" data-id=\"a2f6aac\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-68055fa elementor-widget elementor-widget-image\" data-id=\"68055fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"932\" height=\"572\" src=\"https:\/\/t21learning.institutlejeune.org\/wp-content\/uploads\/2023\/06\/segment_posterieur_oeil-1.jpeg\" class=\"attachment-large size-large wp-image-3899\" alt=\"Les pathologies du segment post\u00e9rieur de l&#039;oeil chez les personnes porteuses de trisomie 21\" srcset=\"https:\/\/t21learning.institutlejeune.org\/wp-content\/uploads\/2023\/06\/segment_posterieur_oeil-1.jpeg 932w, https:\/\/t21learning.institutlejeune.org\/wp-content\/uploads\/2023\/06\/segment_posterieur_oeil-1-300x184.jpeg 300w, https:\/\/t21learning.institutlejeune.org\/wp-content\/uploads\/2023\/06\/segment_posterieur_oeil-1-768x471.jpeg 768w\" sizes=\"(max-width: 932px) 100vw, 932px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-a45ba83\" data-id=\"a45ba83\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-06c476e elementor-widget elementor-widget-toggle\" data-id=\"06c476e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-7091\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-7091\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">CHAPTER OUTLINE<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-7091\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-7091\"><p><a href=\"https:\/\/t21learning.institutlejeune.org\/en\/the-eye-and-vision-in-individuals-with-trisomy-21\/\">1- The eye and vision<\/a><\/p><p>\u00a0<\/p><p><a href=\"https:\/\/t21learning.institutlejeune.org\/en\/related-pathologies-of-the-eyes-in-individuals-with-trisomy-21\/\">2- Related pathologies of the eye<\/a><\/p><p>\u00a0<\/p><p><a href=\"https:\/\/t21learning.institutlejeune.org\/en\/vision-disorders-trisomy-21\/\">3- Vision disorders<\/a><\/p><p>\u00a0<\/p><p><a href=\"https:\/\/t21learning.institutlejeune.org\/en\/anterior-segment-eye-diseases-trisomy-21\/\">4- Anterior segment eye diseases<\/a><\/p><p>\u00a0<\/p><p><strong><a href=\"https:\/\/t21learning.institutlejeune.org\/en\/posterior-segment-eye-diseases-in-individuals-with-trisomy-21\/\">5- Posterior segment eye diseases<\/a><\/strong><\/p><p>\u00a0<\/p><p><a href=\"https:\/\/t21learning.institutlejeune.org\/en\/neuro-ophthalmology-and-trisomy-21\/\">6- Neuro-ophtalmology<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-da3cd7c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"da3cd7c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-18c48beb\" data-id=\"18c48beb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6b33d20 elementor-widget elementor-widget-spacer\" data-id=\"6b33d20\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3acff4c elementor-widget elementor-widget-text-editor\" data-id=\"3acff4c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Although not specific to Trisomy 21, certain pathologies of the posterior segment of the eye are more frequently associated with people with Trisomy 21 than with the neurotypical population. They fall into two categories: retinal anomalies and pathologies, and optic nerve pathologies.<\/p><p>\u00a0<\/p><p>Find out more about their characteristics and the recommendations for their management from Dr. Herv\u00e9 Walti, pediatrician at the Institut J\u00e9r\u00f4me Lejeune, in the video and accompanying fact sheet. For the full chapter, click on the links on the right of the page.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-985d68f elementor-widget elementor-widget-spacer\" data-id=\"985d68f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ed6e280 elementor-widget elementor-widget-video\" data-id=\"ed6e280\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/youtu.be\\\/2Vj1lVdWs5A&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cb49cf1 elementor-widget elementor-widget-spacer\" data-id=\"cb49cf1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-948790a elementor-align-center elementor-widget elementor-widget-button\" data-id=\"948790a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/t21learning.institutlejeune.org\/wp-content\/uploads\/2023\/08\/3.5-Posterior-Segment-Eye-Diseases-EN.pdf\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Download the Summary Sheet<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e571d9 elementor-widget elementor-widget-spacer\" data-id=\"2e571d9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-09d9e5d elementor-widget elementor-widget-text-editor\" data-id=\"09d9e5d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Discover below the presentation associated with this video on the subject of &#8220;Ophthalmological pathologies&#8221;.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-057dae3 elementor-widget elementor-widget-spacer\" data-id=\"057dae3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e001740 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e001740\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-59243b4\" data-id=\"59243b4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6cb3a1a elementor-widget elementor-widget-shortcode\" data-id=\"6cb3a1a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\"><div class=\"_df_book df-lite\" id=\"df_4197\"  _slug=\"3-5-pathologies-du-segment-posterieur-de-loeil-en\" data-title=\"3-5-pathologies-du-segment-posterieur-de-loeil-en\" wpoptions=\"true\" thumbtype=\"\" ><\/div><script class=\"df-shortcode-script\" nowprocket type=\"application\/javascript\">window.option_df_4197 = {\"outline\":[],\"autoEnableOutline\":\"false\",\"autoEnableThumbnail\":\"false\",\"overwritePDFOutline\":\"false\",\"direction\":\"1\",\"pageSize\":\"0\",\"source\":\"https:\\\/\\\/t21learning.institutlejeune.org\\\/wp-content\\\/uploads\\\/2023\\\/06\\\/5.-PATHOLOGIE-SEGMENT-POSTERIEUR-DE-LOEIL_VFPN-eng.pdf\",\"wpOptions\":\"true\"}; if(window.DFLIP && window.DFLIP.parseBooks){window.DFLIP.parseBooks();}<\/script><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2c73462 elementor-widget elementor-widget-spacer\" data-id=\"2c73462\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-032f426 elementor-align-justify btn-refs elementor-widget elementor-widget-button\" data-id=\"032f426\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">See references<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-4b8f4e4 div-refs div-refs-closed elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4b8f4e4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-61edc05\" data-id=\"61edc05\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fd3fdda elementor-widget elementor-widget-text-editor\" data-id=\"fd3fdda\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Ahmad A, Pruett RC. The fundus in mongolism. Arch Ophthalmol. 1976 May;94(5):772-6.<\/li><li>AlAhmadi BO, Alsulaiman SM, Arevalo JF. Retinal Detachment in Down Syndrome: Characteristics and Surgical Outcomes. J Ophthalmol. 2016;2016:6971591.<\/li><li>Al-Hemidan AI, Al-Hazzaa SA, Chavis P, Al-Hussein H. Optic disc elevation in Down syndrome. Ophthalmic Genet. 1999 Mar;20(1):45-51.<\/li><li>Aziz HA, Ruggeri M, Berrocal AM. Intraoperative OCT of bilateral macular coloboma in a child with Down syndrome. J Pediatr Ophthalmol Strabismus. 2011 Jul 19;48 Online:e37-9.<\/li><li>Brichard B, Vermylen C, De Potter P, Casteels I. Down syndrome: possible predisposition to retinoblastoma. Med Pediatr Oncol. 2003 Jul;41(1):73-4.<\/li><li>Catalano RA, Simon JW. Optic disk elevation in Down&#8217;s syndrome. Am J Ophthalmol. 1990 Jul 15;110(1):28-32.<\/li><li>Csincsik L, Nelson R, Walpert MJ, Peto T, Holland A, Lengyel I. Increased choroidal thickness in adults with Down syndrome. Alzheimers Dement (Amst). 2021 Mar 17;13(1):e12170.<\/li><li>da Cunha RP, Moreira JB. Ocular findings in Down&#8217;s syndrome. Am J Ophthalmol. 1996 Aug;122(2):236-44.<\/li><li>Esmaili N, Bradfield YS. Pseudotumor cerebri in children with Down syndrome. Ophthalmology. 2007 Sep;114(9):1773-8<\/li><li>Fimiani F, Iovine A, Carelli R, Pansini M, Sebastio G, Magli A. Incidence of ocular pathologies in Italian children with Down syndrome. Eur J Ophthalmol. 2007 Sep-Oct;17(5):817-22.<\/li><li>Fong AH, Shum J, Ng AL, Li KK, McGhee S, Wong D. Prevalence of ocular abnormalities in adults with Down syndrome in Hong Kong. Br J Ophthalmol. 2013 Apr;97(4):423-8.<\/li><li>Fuerst PG, Koizumi A, Masland RH, Burgess RW. Neurite arborization and mosaic spacing in the mouse retina require DSCAM. Nature. 2008 Jan 24;451(7177):470-4.<\/li><li>Fulcher T, Griffin M, Crowley S, Firth R, Acheson R, O&#8217;Meara N. Diabetic retinopathy in Down&#8217;s syndrome. Br J Ophthalmol. 1998 Apr;82(4):407-9.<\/li><li>Gardiner C, Lanigan B, O&#8217;Keefe M. Postcataract surgery outcome in a series of infants and children with Down syndrome. Br J Ophthalmol. 2008 Aug;92(8):1112-6.<\/li><li>Haseeb A, Huynh E, ElSheikh RH, ElHawary AS, Scelfo C, Ledoux DM, Maidana DE, Elhusseiny AM. Down syndrome: a review of ocular manifestations. Ther Adv Ophthalmol. 2022 Jun 30;14:25158414221101718.<\/li><li>Heindl LM, Naumann GO, Kruse FE, Holbach LM. Aggressive metastasising adenocarcinoma of the retinal pigment epithelium with trisomy 21. Br J Ophthalmol. 2008 Mar;92(3):389-91.<\/li><li>Jaeger EA. Ocular findings in Down&#8217;s syndrome. Trans Am Ophthalmol Soc. 1980;78:808-45.<\/li><li>Krinsky-McHale SJ, Silverman W, Gordon J, Devenny DA, Oley N, Abramov I. Vision deficits in adults with Down syndrome. J Appl Res Intellect Disabil. 2014 May;27(3):247-63.<\/li><li>Laguna A, Barallobre MJ, Marchena M\u00c1, Mateus C, Ram\u00edrez E, Mart\u00ednez-Cue C, Delabar JM, Castelo-Branco M, de la Villa P, Arbon\u00e9s ML. Triplication of DYRK1A causes retinal structural and functional alterations in Down syndrome. Hum Mol Genet. 2013 Jul 15;22(14):2775-84.<\/li><li>Le Grignou M, Bleriot A, Nizon M, Pacquement H, Houdayer C, Thebaud E, Le Meur G, Isidor B. Bilateral retinoblastoma due to a germline mutation of RB1 in a child with down syndrome. Ophthalmic Genet. 2019 Feb;40(1):86.<\/li><li>Liza-Sharmini AT, Azlan ZN, Zilfalil BA. Ocular findings in Malaysian children with Down syndrome. Singapore Med J. 2006 Jan;47(1):14-9.<\/li><li>Mangalesh S, Vinekar A, Jayadev C, Kemmanu V, Bhat M, Sivakumar M, Bauer N, Webers C, Shetty B. Spectral Domain Optical Coherence Tomography in Detecting Sub-Clinical Retinal Findings in Asian Indian Children with Down Syndrome. Curr Eye Res. 2019 Aug;44(8):901-907.<\/li><li>Moll AC, Imhof SM, Bleeker-Wagemakers EM, Den Otter W, Bouter LM, Koten JW, Tan KE. Prevalence of mental retardation in patients with hereditary retinoblastoma. Ophthalmic Genet. 1997 Dec;18(4):217-20.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-8ff0ac2\" data-id=\"8ff0ac2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ca86577 elementor-widget elementor-widget-text-editor\" data-id=\"ca86577\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Moll A, Imhof SM, Bouter L, den Otter W, Koten JW. An infant with Down syndrome and retinoblastoma. A possible non-fortuitous association. Ophthalmic Genet. 2002 Jun;23(2):135-6.<\/li><li>Mu\u00f1oz-Ortiz J, Charry-S\u00e1nchez JD, Bechara-Arango I, Blanco-Becerra M, Talero-Guti\u00e9rrez C, Gomez-Suarez M, de-la-Torre A. Down syndrome: a systematic review Prevalence of ophthalmological manifestations in pediatric and adolescent populations with of the literature. Syst Rev. 2022 Apr 22;11(1):75.<\/li><li>Nicholson R, Osborne D, Fairhead L, Beed L, Hill CM, Lee H. Segmentation of the foveal and parafoveal retinal architecture using handheld spectral-domain optical coherence tomography in children with Down syndrome. Eye (Lond). 2022 Jan 10.<\/li><li>O&#8217;Brien S, Wang J, Smith HA, Donaldson DL, Haider KM, Roberts GJ, Sprunger DT, Neely DE, Plager DA. Macular structural characteristics in children with Down syndrome. Graefes Arch Clin Exp Ophthalmol. 2015 Dec;253(12):2317-23.<\/li><li>Parsa CF, Almer Z. Supranumerary optic disc vessels may indicate reduced systemic angiogenesis in Down syndrome. Br J Ophthalmol. 2008 Mar;92(3):432-3.<\/li><li>Patja K, Pukkala E, Sund R, Iivanainen M, Kaski M. Cancer incidence of persons with Down syndrome in Finland: a population-based study. Int J Cancer. 2006 Apr 1;118(7):1769-72.<\/li><li>Panagopoulos A, Chalioulias K, Murray AT. Bilateral congenital hamartomas of the retinal pigment epithelium in a patient with Down&#8217;s syndrome. Eye (Lond). 2008 May;22(5):735-6.<\/li><li>Postolache L. Abnormalities of the Optic Nerve in Down Syndrome and Associations With Visual Acuity. Front Neurol. 2019 Jun 14;10:633.<\/li><li>Postolache L, De Jong C, Casimir G. Illustration of tessellation in Down syndrome. Ophthalmic Genet. 2020 Apr;41(2):135-145.<\/li><li>Postolache L, Monier A, Lhoir S. Neuro-Ophthalmological Manifestations in Children with Down Syndrome: Current Perspectives. Eye Brain. 2021 Jul 21;13:193-203.<\/li><li>Santoro SL, Atoum D, Hufnagel RB, Motley WW. Surgical, medical and developmental outcomes in patients with Down syndrome and cataracts. SAGE Open Med. 2017 Jun 19;5:2050312117715583.<\/li><li>Satg\u00e9 D, Gembara P, Sasco AJ, Francannet C, Desjardins L, Vekemans M, Demeocq F. An infant with Down syndrome and retinoblastoma. A possible non-fortuitous association. Ophthalmic Genet. 2001 Jun;22(2):117-23.<\/li><li>Satg\u00e8 D, Schorderet DF, Balmer A, Beck-Popovic M, Addor MC, Beckmann JS, Munier FL. Association Down syndrome-retinoblastoma: a new observation. Ophthalmic Genet. 2005 Sep;26(3):151-2.<\/li><li>Schneier AJ, Heidary G, Ledoux DM. Optic nerve appearance in patients with Down syndrome. J Pediatr Ophthalmol Strabismus. 2013 Jan-Feb;50(1):60.<\/li><li>Sherk MC, Williams TD. Disc vascularity in Down&#8217;s syndrome. Am J Optom Physiol Opt. 1979 Aug;56(8):509-11.<\/li><li>T\u0103taru CI, Voinea LM, T\u0103taru CP, Sima G. Clinical and therapeutic particularities of congenital cataracts in pediatric patients with Down syndrome. Rom J Ophthalmol. 2020 Apr-Jun;64(2):168-175.<\/li><li>Terai T, Eda S, Sugasawa J, Tonari M, Matsuo J, Oku H, Ikeda T. Ocular findings in Japanese children with Down syndrome: the course of visual acuity and refraction, and systemic and ocular anomalies. Clin Ophthalmol. 2018 Aug 31;12:16.<\/li><li>Ugurlu A, Altinkurt E. Ophthalmologic Manifestations and Retinal Findings in Children with Down Syndrome. J Ophthalmol. 2020 Feb 7;2020:9726261. 37-1643.<\/li><li>Walpert MJ, Normando EM, Annus T, Jennings SR, Wilson LR, Watson P, Zaman SH, Cordeiro MF, Holland AJ. Age-related retinal thickness in Down&#8217;s syndrome: A high-risk population for dementia. Alzheimers Dement (Amst). 2019 Nov 5;11:744-751.<\/li><li>Williams EJ, McCormick AQ, Tischler B. Retinal vessels in Down&#8217;s syndrome. Arch Ophthalmol. 1973 Apr;89(4):269-71.<\/li><li>Yonemoto Y, Morishita S, Fukumoto M, Mimura M, Sato T, Kida T, Kojima S, Oku H, Sugasawa J, Ikeda T. Bilateral rhegmatogenous retinal detachment due to unusual retinal degeneration in Down syndrome: A case report. 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